Fig. 3

Transcriptome analysis of MOC1 and MOC1-HPV cell lines. A Number of differentially expressed genes in MOC1 and MOC1-HPV cell lines. Genes with an adjusted p value < 0.05 and fold change > 1 were considered differentially expressed. B–D The twenty most significantly enriched GO biological process terms with an adjusted p value < 0.05 comparing MOC1-HPV K1 to MOC1 (B), MOC1-HPV K1 to MOC1-HPV K3 (C), and MOC1-HPV K3 to MOC1 (D) are shown. The position of the dots relates to the GeneRatio, which is the fraction of all differentially expressed genes that are found in the respective GO term. The size and color of the dots represent the number of differentially expressed genes in the pathway and adjusted p value, respectively. Color-coding of the squares next to the biological terms refers to the observed cell phenotype—red: cell migration, blue: angiogenesis, green: cell‒cell contacts