Fig. 3
From: Insulin alleviates murine colitis through microbiome alterations and bile acid metabolism
Insulin modulates the intestinal microbiota of DSS-treated mice. WT mice were treated with DSS for 5 days, followed by 3 days of normal drinking water, and the mice were treated with PBS (n = 6) or insulin (n = 6) intraperitoneally on day 3, day 5 and day 7. A Microbial richness and diversity in the PBS- and insulin-treated mice based on the Chao1 index and the Shannon index. B The impact of insulin on the β-diversity of microbial communities was analyzed by unweighted UniFrac metrics and weighted UniFrac metrics. C Relative abundances of OTUs at the phylum and family levels in the gut microbiota of all the groups. D Relative abundances of OTUs of the genera Ruminococcaceae, Lachnospiraceae, Pirellulaceae, Ruminococcus_1, ASF356, Blautia, Aeromonas, Ruminococcaceae_NK4A214_group, Enterorhabdus, Pir4_lineage and Pirellula