Fig. 5

Nucleotide and IP metabolism are of prognostic relevance for MB patients. A Workflow showing all steps of the survival analysis using maximally selected rank statistics. The separation of ICGC and MAGIC cohorts into high and low gene expression groups has been performed using the R package maxstat as described in the Additional file 1. B, C Kaplan–Meier curves showing the overall survival of patients from MAGIC and ICGC cohorts. Patients have been divided into two groups depending on RNA expression levels of genes involved in the metabolism of B pyrimidines or C inositol phosphates. Log-rank test was used to calculate p-values, and p < 0.05 was considered significant. The flowchart was created using Biorender.com