Fig. 2

Functional characterisation of metabolic G3/G4 clusters in examined cohorts. IPA canonical pathway analysis of upregulated DEGs comparing solely clusters dominated by G3/G4 MB has been performed. Pathways are presented for A I_G3/4.1, B I_G3/4.2, C I_G3/4.3, D M_G3/4.1, E M_G3/4.2, F M_G3/4.3. Pathways that overlap in content across clusters are printed in bold. Behind each pathway, the number of DEGs matching this pathway is listed in brackets. G Sankey plot illustrating relationships between metabolic clusters in ICGC and MAGIC based on DEGs of each cluster as outlined in the Additional file 1. The width of each bar representing a cluster refers to the total number of DEGs which overlap with clusters from the other cohort. IP = inositol phosphate; EMT = epithelial–mesenchymal transition