Fig. 1

Established MB groups differ in metabolic gene expression with association to patients’ prognoses. A Heatmaps showing the expression of metabolic genes from the ccmGDB across 139 samples from the ICGC cohort and 763 samples from the MAGIC cohort ordered by unsupervised hierarchical clustering. For the MAGIC cohort, genes are in the same order as for the ICGC cohort. Annotation bars on the column side illustrate the amplification status of MYC (only ICGC), correlation with published methylation G3/G4 subgroups [2], and the samples’ MB group affiliation from top to bottom. B, C Overall survival of patients from B ICGC and C MAGIC cohort. Patients have been grouped into metabolic clusters identified in A. Log-rank test was used to calculate p-values, and p < 0.05 was considered significant. MBNOS = MB not other specified; wt = wildtype