Fig. 7
From: Intraparenchymal convection enhanced delivery of AAV in sheep to treat Mucopolysaccharidosis IIIC
Immune reactions pre- and post-injection. Total IgG antibody responses against AAV9 and AAV-TT capsid proteins measured by ELISA on day 0 (the day of surgery) and 3 weeks post-surgery (at necropsy) in study 1 (A, B) and study 2 (C–J). A number of sheep showed pre-existing antibodies to the AAV-capsids that were still evident at necropsy. D One sheep developed an immune response to the AAV capsid. J One sheep (highlighted in red) was sacrificed on the day of surgery due to an adverse event but had no IgG antibodies against the capsid