Fig. 3
From: Intraparenchymal convection enhanced delivery of AAV in sheep to treat Mucopolysaccharidosis IIIC
GFP expression from different injection sites in sheep brains in study 1. Images revealing the pattern of GFP expression 3 weeks post AAV9-GFP injection at 10× magnification. After delivery into the lateral ventricles transduced cells can be visualised on the A dorsal and B ventral surface of the ventricle. GFP transduced cells can be visualised in the C striatum, D medial geniculate nucleus , E motor cortex, F brainstem and G thalamus after direct injection into the CS. For WM injections, GFP positivity was detected in the H WM and the I neurons adjacent to the injection site. Scale bar = 100 µm