Fig. 1.
From: Intraparenchymal convection enhanced delivery of AAV in sheep to treat Mucopolysaccharidosis IIIC
Experimental protocol for AAV distribution studies. A Overview of treatment protocol and tissue analysis. B Different flow rates in 0.4% agarose gel phantoms. Experimental groups used in study 1 C and study 2 D. E Schematic of injection sites for Corpus Striatum (CS), White Matter (WM), Subcortical zone (SC) and Brainstem (BS) from a lateral and superior view. F Syringe driver used for AAV delivery. G Example surgical screenshot from Brainlab showing target accuracy. H Schematic of mediolateral sagittal brain levels 1-5 used for immunohistochemical analysis