Table 3 Research reports of mitochondrial transplantation for I/R injury
From: Mitochondrial transplantation as a novel therapeutic strategy for cardiovascular diseases
Species | Type of model | Mitochondrial sources | Injection sites and methods | Therapeutic outcomes | References |
|---|---|---|---|---|---|
New Zealand white rabbits | Focal ischemia | Left ventricular | Direct injection into regional ischemia zone of the heart | Recovery of myocardial function | McCully et al. [37] |
New Zealand white rabbits | Focal ischemia | Pectoralis major muscle tissues | Direct injection into regional ischemia zone of the heart | Reduced myocardial infarct size and enhanced regional myocardial function post-reperfusion | Masuzawa et al. [32] |
New Zealand white rabbits | Global or regional ischemia | (1) xenograft: human cardiac fibroblasts (2) autograft: liver | Intracoronary injection (120Â min after reperfusion) | Reduced infarct size and enhanced myocardial function | Cowan et al. [38] |
Yorkshire pigs | Focal ischemia | pectoralis major muscle tissues | Direct injection under the endocardium (1Â min before reperfusion) | No change in inflammatory and cytokine activation markers; decreased infarct size but no change in global function | Kaza et al. [71] |
Yorkshire swine | Focal ischemia | Pectoralis major muscle tissues | Intracoronary injection (immediately on reperfusion) | Improved myocardial function, perfusion, and infarct size | Shin et al.[72] |
Yorkshire pigs | Global ischemia | Pectoralis major muscle; swine cardiac fibroblast cell | Intracoronary injection: 15Â min or 2Â h post-reperfusion | Preserved myocardial function and oxygen consumption and, decreased infarct size | Guariento et al. [78] |
Yorkshire pigs | Focal ischemia | Pectoralis major muscle tissues | Intracoronary injection (15Â min before regional ischemia) | Reduced myocardial infarct size, improved myocardial function | Guariento et al. [73] |
Yorkshire pigs | Focal ischemia | Pectoralis major muscle tissues | Direct injection into the left coronary ostium | Reduced myocardial infarct size and enhanced regional and global myocardial function post-reperfusion | Blitzer et al. [79] |
C57BL/6 | Focal ischemia | gastrocnemius muscle | Intracoronary injection (10Â min before organ harvest and 5Â min after transplantation) | Enhanced graft function and decreased graft tissue injury | Moskowitzova et al. [74] |
Zucker Fatty rats | Global ischemia | Pectoralis major muscle tissues | Delivery to the coronary arteries via the aortic cannula | Recovery of left ventricular function, reduction of infarct size and area at risk | Doulamis et al. [76] |
C57BL/6 | Focal ischemia | Not reported | Direct injection at myocardium of the left ventricle | Inhibition of cardiomyocyte apoptosis in vitro | Sun et al. [39] |