Table 2 Different mitochondria transplantation methods in safety, efficacy and flexibility
From: Mitochondrial transplantation as a novel therapeutic strategy for cardiovascular diseases
Methods | Safety | Efficacy | Fexibility |
|---|---|---|---|
Co-incubation | Low accuracy High risk of mitochondria damage | Moderate transfer efficiency mtDNA retention up to 12 passages | Reduced manipulation of large numbers of transplant recipient cells; easy to realize |
Microinjection | Potentially harmful for the target, high risk of mitochondria damage | mtDNA is retained from 6–10 weeks after treatment | Limited number of cells transplanted |
EVs | Mitochondrial and cellular integrity preservation | mtDNA retention not known | Low manipulation, easy to realize |