Table 1 Mendelian randomization results of causal effect of omega-3 fatty acids on type 2 diabetes in different clusters
| Â | Method | No. SNPs | Causal estimate | Heterogeneity | Pleiotropy | |||
|---|---|---|---|---|---|---|---|---|
OR (95% CI) | P | Q | P | Intercept | P | |||
Total | IVW | 30 | 0.97 (0.87–1.08) | 0.600 | 250.45 | 4.16 × 10–37 | – | – |
|  | MR Egger | 30 | 1.05 (0.90–1.21) | 0.556 | 233.47 | 2.71 × 10–34 | − 0.0095 | 0.165 |
Weighted median | 30 | 1.08 (1.03–1.13) | 0.002 | – | – | – | – | |
Simple mode | 30 | 0.78 (0.57–1.06) | 0.120 | – | – | – | – | |
Weighted mode | 30 | 1.08 (1.03- 1.13) | 0.002 | – | – | – | – | |
Cluster 1 | IVW | 7 | 0.52 (0.45–0.59) | 2.91 × 10–21 | 10.33 | 0.111 | - | - |
|  | MR Egger | 7 | 0.55 (0.43–0.71) | 0.006 | 9.57 | 0.088 | -0.0055 | 0.555 |
Weighted median | 7 | 0.59 (0.50–0.69) | 6.62 × 10–11 | – | – | – | – | |
Simple mode | 7 | 0.60 (0.43–0.83) | 0.023 | – | – | – | – | |
Weighted mode | 7 | 0.60 (0.49–0.73) | 0.002 | – | – | – | – | |
Cluster 2 | IVW | 10 | 1.10 (1.06–1.15) | 4.41 × 10–6 | 6.13 | 0.727 | – | – |
|  | MR Egger | 10 | 1.09 (1.03–1.16) | 0.021 | 5.73 | 0.677 | 0.0025 | 0.549 |
Weighted median | 10 | 1.10 (1.05–1.15) | 0.0001 | – | – | – | – | |
Simple mode | 10 | 1.04 (0.91–1.19) | 0.560 | – | – | – | – | |
Weighted mode | 10 | 1.09 (1.04–1.15) | 0.006 | – | – | – | – | |