Fig. 7
DPSC-Exos alleviated IFN-γ-caused AQP5 downregulation in salivary gland epithelial cells (SGEC) via GPER mediated cAMP-PKA-CREB pathway. A–E Western blot analysis AQP5, GPER, p-PKA, and p-CREB in SGEC. F The cAMP concentration in SGEC lysate was detected by ELISA. G The intracellular Ca2+ level of SGEC was measured by flow cytometry. Data are presented as the mean ± SD, n = 3. Significant effect of the treatment, *p < 0.05, **p < 0.01, ***p < 0.001