Fig. 6

DPSC-Exos treatment alleviated SS-like symptoms in NOD/ltj mice. A Scheme of animal experiment and treatment. B The saliva flow rate, C H&E stained histological images of mice submandibular glands. Immunohistochemistry analysis of AQP5 (D, E) and GPER (F, G) expression in mice submandibular glands. H The anti-SSA/SSB levels of NOD/ltj mice serum were detected by ELISA. Western blot (I, J) and RT-qPCR analysis (K) of AQP5 expression in mice submandibular. Scale bar: 100 μm. Data are presented as the mean ± SD, n = 6. Significant effect of the treatment, *p < 0.05, **p < 0.01, ***p < 0.001