Fig. 4

Transcriptome analysis of salivary gland epithelial cells treated with or without DPSC-Exos. A The Principal Component Analysis (PCA). B Volcano plot showing differentially expressed genes (DEGs). C Gene ontology analysis. D KEGG analysis enriched GPER-related pathways among DEGs. E STRING database shows the interaction among the cAMP signaling pathway, salivary secretion, and estrogen signaling pathway, and F Venn analysis of the genes among the cAMP signaling pathway, salivary secretion, and estrogen signaling pathway. All DEGs are screened based on P-value < 0.05 and |fold change| > 1