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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: A novel camptothecin derivative, ZBH-01, exhibits superior antitumor efficacy than irinotecan by regulating the cell cycle

Fig. 2

Inhibitory effect of ZBH-01 on TOP1. A TOP1-catalyzed DNA relaxation was inhibited by CPT-11, SN-38, and ZBH-01. The DNA strand breakage induced by TOP1 was evaluated by the conversion of the double-stranded supercoiled DNA to a relaxed form. The position of supercoiled DNA (Sc) and relaxed DNA (R) are indicated. B The image of immunoblot showed the signals of TOP1 band in the DNA-containing fractions in LS174T cells after treatment with ZBH-01, CPT-11, and SN38. The fractions are indicated by numbers

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Journal of Translational Medicine

ISSN: 1479-5876

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