Fig. 11From: A novel camptothecin derivative, ZBH-01, exhibits superior antitumor efficacy than irinotecan by regulating the cell cycleHypothetical ZBH-01 mechanisms. The DNA damage caused by ZBH-01 induces not only cell cycle arrest but also apoptosis. CCNA2, CDK2, MYBL2, CHEK1, BAX, BCL2L1, caspase 3, and other genes might be regulated by ZBH-01Back to article page