Fig. 5
From: ST6GALNAC4 promotes hepatocellular carcinogenesis by inducing abnormal glycosylation
ST6GALNAC4 exerted an immunosuppressive effect by inducing CD8+ T cell depletion in HCC. A KM curve in orthotopic liver model in both nude mice and C57BL/6 mice with shst6galnac4 and shNC hep1-6 cells. B Tumors in orthotopic liver model in C57BL/6 mice. C Tumor weights in orthotopic liver model in C57BL/6 mice were recorded. D Correlation between the expression of ST6GALNAC4 and exhaustion markers of T cells in TCGA data set. E Proportions of CD8+ and CD4+ T cell populations between shst6galnac4 group and control group on flow cytometry. F CD8 immunohistochemistry in tumors between shst6galnac4 group and control group on flow cytometry. Proportions of INF-\(\gamma\) (G), TGF-\(\alpha\) (H), perforin (I), and Granzyme B (J)+ T cell populations between shst6galnac4 group and control group on flow cytometry. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. ns, not significant