Fig. 7

Regulatory modes on TFAP2 expression The TFAP2 expression is altered by a epigenetic modification to alter the accessibility of TFAP2 enhancer or promoter; b transcriptional regulation, e.g., directly interacting with cis-regulatory element of TFAP2 gene; c post-transcriptional regulation, e.g., modifying the stability of TFAP2 mRNA and d posttranslational regulation, e.g., inducing accumulation or degradation of TFAP2 protein. Only validated direct protein–protein interaction and DNA/RNA–protein interaction are shown. (Created with BioRender.com)