Fig. 1

Regulatory modes of TFAP2 on downstream targets Regulatory modes of TFAP2 on downstream targets, a epigenetic modification on chromatin conformation to alter its accessibility to the regulatory region; b directly or c competitive binding on regulation region of the target gene and d posttranslational regulation, such as translocation shifting. Only validated direct protein–protein interaction and DNA/RNA–protein interaction are shown. (Created with BioRender.com)