Fig.1
From: Alterations in the microenvironment and the effects produced of TRPV5 in osteoporosis
Schematic overview. TRPV5 demonstrates multi-level associations with OP, encompassing such as bone phenotype, bone tissue cells, pH, and molecular mechanism. At the Bone Phenotype level, aberrant TRPV5 function may result in accelerated bone aging, dysregulated bone resorption, and diminished mineralization of bone calcium. The Bone Tissue Cells level primarily involves various hormones acting on TRPV5 to exert effects on distinct bone tissue cells. The Molecular Mechanism level primarily encompasses phosphorylation, glycosylation, and ubiquitination process. Alterations in the pH microenvironment exert a complex impact on the balance of the skeletal system