Fig. 3

Oncoprint of genomic alterations in CNS tumors. Heatmap of genomic alterations in the series of 82 tumors. Individual genes are represented as rows, and tumors are represented as columns. The bars at the top of the figure indicate the number of cumulative events (putative drivers) identified in the corresponding sample at baseline. The colors represent the six types of underlying genomic alterations as indicated on the right. Concordance between methylation classification or NGS results and pathology diagnosis, the potential availability of targeted therapies, and the pathology diagnosis (indicated in different colors) are also shown. The genes (rows) are sorted by their alteration frequency in the cohort, as noted on the left. When two events affect the same gene in a sample, they are represented in the same slot. Different colors and sizes of rectangles distinguish the type of alterations, as indicated in the panel on the right