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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Screening of immune-related secretory proteins linking chronic kidney disease with calcific aortic valve disease based on comprehensive bioinformatics analysis and machine learning

Fig. 5

PPI analysis between CKD-associated secretory proteins and CAVD key genes, and followed by enrichment analysis of the PPI-screened nodes. A The PPI network of module1 genes with the top1 highest score based on Cytoscape plug-in MCODE analysis. Salmon nodes are marked as members of CAVD key genes, yellow nodes as members of CKD-associated secretory proteins, while red nodes as common genes of the two sets. B The PPI network of module2 genes with the top2 highest score according to MCODE analysis. C–F The bubble plots showing the GO enrichment analysis results, including biological process (C), cellular component (D), and molecular function (E) of genes included in module1 and module2. F Circos plot representing the KEGG analysis results of genes included in module1 and module2. PPI protein-protein interaction, CKD chronic kidney disease, CAVD calcific aortic valve disease, MCODE molecular complex detection

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Journal of Translational Medicine

ISSN: 1479-5876

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