Fig. 2

The integration of CAVD datasets and differential expression analysis of the integrated CAVD dataset. A PCA of three original CAVD datasets before batch-effect correction. B PCA of the integrated CAVD dataset after batch-effect correction. C The volcano plot representing CAVD DEGs in the integrated CAVD dataset. The upregulated genes are presented in red dots, whereas, the downregulated genes are presented in blue dots. D The heatmap showing the top 30 upregulated and 30 downregulated DEGs in the integrated CAVD dataset. CAVD calcific aortic valve disease, PCA principal component analysis, DEGs differentially expressed genes