Causality of genetically determined metabolites and metabolic pathways on osteoarthritis: a two-sample mendelian randomization study

Table 2 Significant Metabolic Pathways Involved in different OA phenotypes

OA	Metabolite set	Total	Hits	Expect	P value	Holm P	FDR
All OA	Caffeine metabolism	10	2	0.039	5.65E− 04	0.047	0.047
Thumb OA	Arginine biosynthesis	14	4	0.137	5.58E− 06	4.69E− 04	4.69E− 04
Thumb OA	Alanine, aspartate and glutamate metabolism	28	4	0.273	1.05E− 04	0.009	0.004
Thumb OA	Aminoacyl-tRNA biosynthesis	48	4	0.469	8.91E− 04	0.073	0.025
Thumb OA	D-Glutamine and D-glutamate metabolism	6	2	0.059	0.00131	0.106	0.027
Thumb OA	Glyoxylate and dicarboxylate metabolism	32	3	0.312	0.00316	0.252	0.053
Thumb OA	Arginine and proline metabolism	38	3	0.371	0.00518	0.409	0.073
Hip OA	Aminoacyl-tRNA biosynthesis	48	4	0.375	3.46E− 04	0.029	0.029
Hip OA	Valine, leucine and isoleucine biosynthesis	8	2	0.063	0.00153	0.127	0.064
Hip OA	Caffeine metabolism	10	2	0.078	0.00243	0.200	0.068
KneeHip OA	Caffeine metabolism	10	3	0.085	5.50E− 05	0.005	0.005

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