Cerebellar connectome alterations and associated genetic signatures in multiple sclerosis and neuromyelitis optica spectrum disorder

Table 1 Demographic, clinical and neuropsychological variables

	HCs (n = 228)	MS (n = 208)	NMOSD (n = 200)	p-value
Age (years)	37.0 (21.0)	36.0 (17.0)	41.0 (21.5)	0.003^a,c
Sex (female/male)	124/104	135/73	175/25	< 0.001^a,b,c
Disease state (relapsing/remitting)^*	–	48/149	48/147	0.954
Disease duration (months)	–	19.0 (54.0)	36.0 (52.0)	0.054
Lesion
N (%)	–	208 (100%)	110 (55%)	< 0.001
Volume (cm³)	–	7.6 (16.0)	1.2 (4.0)	< 0.001
EDSS	–	2.0 (2.5)	3.5 (3.0)	< 0.001
CVLT^†	52.0 (10.8)	47.5 (15.0)	47.0 (14.5)	< 0.001^b,c
PASAT^†	51.5 (14.0)	40.0 (17.0)	40.0 (18.0)	< 0.001^b,c
BVMT^†	28.0 (5.8)	27.0 (11.8)	22.0 (12.0)	0.003^c

Data are represented as median (interquartile range) unless stated otherwise
HCs healthy controls, MS multiple sclerosis, NMOSD neuromyelitis optica spectrum disorders, EDSS Expanded Disability Status Scale, CVLT California Verbal Learning Test, PASAT Paced Auditory Serial Addition Test, BVMT Brief Visuospatial Memory Test
^*Data are missing for 16 patients
^†Data are available only for a subset of participants from three hospitals (see Materials and Methods for details)
^aSignificant differences between the two patient groups
^bSignificant differences between the MS patients and HCs
^cSignificant differences between the NMOSD patients and HCs

ISSN: 1479-5876