Fig. 4

Features contributing to the classification between groups. The features contributing to the classification were mainly composed of connectivity that exhibited significant between-group differences. The classification between the patients and HCs mainly relied on morphological connectivity in particular those involving the PMB, SM and SNM, while the classification between the two diseases mainly benefited from functional connectivity that were all involved in the three motor-related modules (i.e., the PMA, PMB and SM). HCs healthy controls, MS multiple sclerosis, NMOSD neuromyelitis optica spectrum disorders, PMA Primary Motor A, PMB Primary Motor B, PNM Primary Non-Motor, SM Secondary Motor, SNM Secondary Non-Motor, PM primary motor cortex, AC1 association cortex, AC2 association cortex, PSS primary/secondary sensory, PS primary sensory cortex, LB limbic regions, IC insular cortex, VN visual network, SMN somatomotor network, DAN dorsal attention network, VAN ventral attention network, LN limbic network, FPN frontoparietal network, DMN default mode network