Fig. 3
Genetic correlates of cerebellar functional connectivity alterations. Transcriptional data explained > 37.5% variance of the cerebellar functional connectivity alterations in MS with the most correlated genes enriched in signaling and ion transport-related processes and preferentially located in excitatory and inhibitory neurons. For NMOSD, around 30% variance of the cerebellar functional connectivity alterations were explained by transcriptional profiles with the most correlated genes enriched in female pregnancy and multi-organism reproductive process in addition to signaling and ion transport-related processes and preferentially located in astrocytes and microglia in addition to excitatory and inhibitory neurons. MS, multiple sclerosis; NMOSD, neuromyelitis optica spectrum disorders. CerebralC cerebral cytoarchitectonic modules, CerebralF cerebral functional modules