Fig. 2

Alterations in cerebellar module-based morphological and functional connectivity. For morphological connectivity, numerous alterations of both increases and decreases were found in the two patient groups. Compared with morphological connectivity, fewer alterations were observed for functional connectivity in the two patient groups that were all characterized by disease-related decreases in particular for connectivity between cerebellar motor modules and cerebral association cortex or high-order networks. HCs healthy controls, MS multiple sclerosis, NMOSD neuromyelitis optica spectrum disorders, PMA Primary Motor A, PMB Primary Motor B, PNM Primary Non-Motor, SM Secondary Motor, SNM Secondary Non-Motor, PM primary motor cortex, AC1 association cortex, AC2 association cortex, PSS primary/secondary sensory, PS primary sensory cortex, LB limbic regions, IC insular cortex, VN visual network, SMN somatomotor network, DAN dorsal attention network, VAN ventral attention network, LN limbic network, FPN frontoparietal network, DMN default mode network