Fig. 1

OSMR deficiency aggravates pressure overload-induced cardiac hypertrophy and reduces survival. A Representative gross morphology and haematoxylin and eosin-stained heart sections of wild-type (WT) or OSMR-KO mice subjected to sham or AB surgery at the indicated times (n = 8 mice per experimental group). B Heart weight to body weight (HW/BW) ratios, lung weight to body weight (LW/BW) ratios and heart weight to tibia length (HW/TL) ratios of WT or OSMR-KO mice at the indicated times (n = 8 mice per experimental group). C Quantification of the cross-sectional area in each group (n = 100–200 cells per experimental group). D Survival rates of mice in each group at eight weeks after sham or AB surgery (n = 12 mice per experimental group). Data are presented as the mean ± SEM. *P < 0.05 compared with the matched control