Fig. 2

Automated image analysis revealed the discrepancy across regions and patient subgroups. a Composition of the stromal cell subsets in invasive margin and tumor center. b Composition of CD8 + T-cell subsets. c Different densities of cell subsets between invasive margin and tumor center. Significance (P value) was determined by paired Wilcoxon signed-rank test. d Clinicopathologic characteristics and cell composition of per patient on multiplex immunofluorescence images