Fig. 7

Characterization of the relationship of the LRscore with cancer progression, the microenvironment, cancer subtype and somatic mutation. A Volcano plot showing that the LRscore was positively correlated with the majority of cancer hallmarks. In the Spearman analysis, a cancer hallmark with P < 0.05 is marked in red (positive correlate) or blue (negative correlate). B Heatmap showing the association between the LRscore and immune cell infiltration level inferred based on xCell analysis. Spearman analysis; *P < 0.05; **P < 0.01; ***P < 0.001. C-E The LRscore was correlated with some indicators of the microenvironment, immune dysfunction/exclusion, and immune phenotype (Spearman analysis). F Sankey chart showing the distribution of different LRscore risk patients across different molecular subtypes of bladder cancer. G Oncoplot showing differences in TMB, TNB and mutated genes between the high- and low-risk groups. H The standard error bars indicate the IC50 values for the two FGFR3-targeted drugs in the low- and high-risk groups, with a lower IC50 typically predicting higher drug sensitivity. Wilcoxon test; ****P < 0.0001