Fig. 6
From: Sp1 promotes tumour progression by remodelling the mitochondrial network in cervical cancer
Sp1 enhanced subcutaneous tumour growth in vivo. A Experimental procedures for producing nude mouse models of subcutaneous tumorigenesis. B and D Subcutaneous nude mouse models and xenograft tumours. C and E The weight and volume of xenograft tumours. F IHC images of Sp1, Ki-67, and TUNEL assays in xenograft tumours of the Sp1-overexpression or Sp1-knockout groups. G and H The protein levels of apoptosis-related proteins were evaluated by Western blot analysis in HeLa subcutaneous xenografts with Sp1 overexpression or Sp1 knockout. I and J Western blot analysis of the levels of Mfn1/2, Drp1, and Opa1 in HeLa subcutaneous xenografts from the Sp1-overexpression or Sp1-knockout groups. K and L Relative glucose and lactate levels were determined in HeLa subcutaneous xenografts from the Sp1-overexpressing or Sp1-knockout groups. *P < 0.05, **P < 0.01, ***P < 0.001