Fig. 4
From: Sp1 promotes tumour progression by remodelling the mitochondrial network in cervical cancer
Sp1 enhanced aerobic glycolysis activity in cervical cancer cells. A DEG expression between the scramble siRNA group and Sp1 siRNA group (left) and DEG expression between the scramble control group and Sp1 group (right). B DEGs between the siRNA group and the Sp1 siRNA group (left) and DEGs between the control group and the Sp1 group (right). C GO analysis of DEGs by biological process. Left panel, scramble siRNA V.S. Sp1 siRNA. Right panel, control Group V.S. Sp1 group. D GO analysis of DEGs by molecular function. Left panel, scramble siRNA V.S. Sp1 siRNA. Right panel, control Group V.S. Sp1 group. Sp1 siR, siRNA against Sp1; scramble siR, control siRNA, control, empty vector, Sp1, vector encoding Sp1. E KEGG signalling pathway analysis of the DEGs. Left panel, scramble siRNA V.S. Sp1 siRNA. Right panel, control Group V.S. Sp1 group. F and G The relative levels of glucose and lactate in cervical cancer cells were treated as indicated. H and I Western blot analysis to detect glycolytic gene expression in cervical cancer cells treated as indicated. All experiments were repeated triplicate individually.*P < 0.05, **P < 0.01, ***P < 0.001