Fig. 1

TSPO ligands suppress plasma-cell formation and antibody secretion in vitro. Purified CD19⁺ B cells were stimulated with CpG + anti-IgM, CpG + anti-IgM + FGIN1-27, or CpG + anti-IgM + Ro5-4864, for 9 days. A–D Representative flow-cytometry results and bar graphs of flow cytometry of CD138⁺ cells, CD27⁺ cells, and CD138⁺CD27⁺ cells in CD19⁺ B cells. E–G Representative flow-cytometry results and bar graphs of CD19⁺ B cells. H, I Concentrations of IgG and IgM in the culture supernatant were determined by ELISA. Data are the mean ± SD of five independent samples. n = 5; *P < 0.05; **P < 0.01; ns: no significant difference