Fig. 9

The analysis of Molecular Dynamics Simulation (MDS) results. A Root mean square deviation (RMSD), radius of gyration (Rg), solvent accessible surface area (SASA) and hydrogen bond (HB) profiles of the NRP-1 with Wnt1, the complexes of β-catenin with APC, Axin, and GSK-3β systems. B The binding mode of NRP-1 to Wnt1, β-catenin to APC, Axin and GSK-3β, respectively. C The specific views of the 2-D ligand interaction among NRP-1 with Wnt1, β-catenin with APC, Axin and GSK-3β, respectively. (B-catenin = β-catenin, GSK-3B = GSK-3β).