Identification of colorectal cancer progression-associated intestinal microbiome and predictive signature construction

Table 1 Demographic and clinical characteristics of CRC patients stratified by CRC progression-related condition

		CRC patients with advanced stage (TMN 3–4) (n = 130)	CRC patients with early stage (TMN 0–2) (n = 62)	P value	Test
Age (years, mean (SD))		57.52 ± 11.96	59.60 ± 10.16	0.240	T-Test
Age (%)	≥ 60	57 (43.80)	27 (43.50)	0.969	Pearson Chi-square
Age (%)	< 60	73 (56.20)	35 (56.50)	0.969	Pearson Chi-square
Gender (%)	male	67 (51.50)	46 (74.20)	0.003**	Pearson Chi-square
Gender (%)	female	63 (48.50)	16 (25.80)	0.003**	Pearson Chi-square
LVI invasion (%)	YES	32 (43.20)	15 (25.40)	0.033*	Pearson Chi-square
LVI invasion (%)	NO	42 (56.80)	44 (74.60)	0.033*	Pearson Chi-square
perineural invasion (%)	YES	49 (67.10)	24 (41.40)	0.003**	Pearson Chi-square
perineural invasion (%)	NO	24 (32.90)	34 (58.60)	0.003**	Pearson Chi-square

The "*" in the upper right corner of the P value indicates the size of the P value: none* for P value ≥ 0.05. * for 0.01 ≤ P < 0.05. ** for 0.001 ≤ P < 0.01

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