Fig. 4

Correlation of CRC progression-related differential intestinal flora with tumor immune infiltrating cells. A Relative abundance strip chart of immune cells in CRC patients grouped by tumor stage. Each bar is a sample, and the vertical coordinate is the predicted relative abundance value of immune cells. The sum of the relative abundance of all immune cells in a single sample is 1, and each color in the graph corresponds to one immune cell. B Heat map of correlation between dominant flora and immune cell abundance in stage I-II group. C Heat map of correlation between dominant flora and immune cell abundance in stage III-IV group. The horizontal coordinates indicate immune cells. The vertical coordinates indicate bacteria. The red color in the graph represents positive correlation. The blue color represents negative correlation. The color depth represents the Pearson correlation coefficient size. The color from light to dark indicates the Pearson correlation coefficient value from small to large. The "*" in the graph indicates the size of P-value: no * for P-value ≥ 0.05, * for 0.01 ≤ P < 0.05, ** for 0.001 ≤ P < 0.01, *** for P < 0.001. D Network diagram of correlation between associated differential intestinal flora and immune cells. Each node represents each gut bacteria or immune cell. The node color represents the grouping. And the connecting line represents the existence of significant correlation between two nodes. The Spearman correlation coefficient value less than 0 (negative correlation) indicates the blue line, and the Spearman correlation coefficient value greater than 0 (positive correlation) indicates the red line