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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Phospholipase A2 regulates autophagy in gouty arthritis: proteomic and metabolomic studies

Fig. 2

GO/KEGG enrichment analysis of differential proteins to characterize their function. A: GO enrichment analysis of elevated expression top30 (screening of 10 GO entries corresponding to the number of proteins greater than 1 in each of the three classifications, sorted by the -log10Pvalue of each entry in descending order), where the x-coordinate is the name of the GO entry and the y-coordinate is the -log10Pvalue. B: Comparison of differentially expressed proteins and all proteins at the KEGG Level2 level. Distribution comparison graph. The horizontal axis is the ratio (%) of proteins annotated to each Level2 metabolic pathway (differential proteins) to the total number of all proteins annotated to the KEGG pathway (differential proteins), the vertical axis indicates the name of the Level2 pathway, and the number to the right of the column represents the number of differentially expressed proteins annotated to that Level2 pathway. C: PPI protein interaction network, select this species/related species (blast e-value: 1e-10) in STRING database to analyze the differential proteins and obtain the interaction relationship of the differential proteins. D: KEGG enrichment analysis top20 (upregulated differential) bubble plot. The x-axis Enrichment Score is the enrichment score and the y-axis is the pathway information of top20. The larger the bubble, the greater the number of differential proteins contained in the entry, and the color of the bubble changes from red–green–blue-violet, the smaller the enrichment p-value and the greater the significance

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