Fig. 4

Analysis of NK-NPC tumor cell subtypes and cellular evolutionary trajectories. A Cell-cell interactions between all cell types about GALECTIN signaling. B Epi1-7 cell subsets were obtained by reduced-dimensional and clustering of Epithelial cells. C The copykat software identifies the benign and malignant epithelial cells, with orange representing copy number increase, blue representing copy number deletion, and gray and black interspersed above representing different chromosomes; pred.aneuploid: malignant; pred.diploid: benign. D The copykat software further identifies malignant tumor cells into two subtypes, tumor subtype1 and tumor subtype2. E The two subtypes, tumor subtype1 and tumor subtype2, were mapped in the TNSE graph. F Expression of LGALS9 and MHC class I molecules in tumor subtype1 and tumor subtype2. G Expression and distribution of KRT5, SSTR2, LMP-1/BNLF2a/b and RPMS1/A73 in tumor subtype1 and tumor subtype2