Fig. 1
Priming hypothesis: (1) The infection by SARS-CoV-2 induced a severe acute inflammatory response through innate immunity activation. (2) The immune cells including macrophages and dendritic (DC), in response to SARS-CoV-2 start the production of inflammatory cytokines, including interleukins IL-6, IL-1, TNF-α and INF-γ, that hyperactivate (3) NK and T cells. (4) Furthermore, Antigen-Presenting Cells (APC cells) efficiently prime CD8 + cytotoxic T cells, CD4 + T helper cells and B cell maturation, (5) maintaining an activated state of tumur-infiltrating lymphocytes and (6) promoting the death of cancer cells
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