Fig. 2

Follow-up analysis of MTAG-IBS results and causal analysis. a Functional annotation of the credible variants associated with MTAG-IBS. b RegulomeDB scores of the credible variants associated with MTAG-IBS. Low scores indicate increasing likelihood of having regulatory function. c Distribution of the credible variants associated with MTAG-IBS across 15 categories of minimum chromatin state. Lower state indicating higher accessibility and states from 1 to 7 refer to open chromatin states. d Genetic correlations (rg) between MTAG-IBS results and 17 phenotypes involving digestive, immunological and psychiatric disorders. Only significant correlations after Bonferroni correction are displayed. e Bar graphs depicting the size of the genomic locus (left), number of candidate SNPs in the locus (center) and number of mapped genes in the genomic locus (right). Genomic loci are displayed by “chromosome: start position-end position”. f Partitioning of the SNP heritability of the MTAG-IBS results using LD Score regression. Enrichment was calculated by dividing the partial heritability of a category by the proportion of SNPs in that category (proportion indicated by color). Only significant enrichments are displayed. g Causal relationships between IBS and neuroticism, depression and anxiety assessed using Causal Analysis Using Summary Effect estimates (CAUSE). Only associations with evidence of causal relationship are displayed