Scheme 1
From: RETRACTED ARTICLE: Palmitoyl transferases act as novel drug targets for pancreatic cancer
Schematic overview of the experimental design. A Various sources of data used in the principal part of this study. B Identification of pancreatic cancer-related ZDHHC. C Pan-cancer analysis examining correlations between ZDHHC3 mRNA levels and immunological elements. The relative infiltrations of TIICs in the TME were analyzed using the ssGSEA algorithm. D Correlation between ZDHHC3 mRNA levels and the immunological profiles of the TME in PAAD. E The relationships between ZDHHC3 expression and mutation landscape in TCGA-PAAD cohort. F Genetic targeting ZDHHC3 in Panc 02 tumor model. G Pharmacological targeting ZDHHCs for pancreatic cancer treatment. TIICs: tumor-infiltrating immune cells; KD: knockdown; TME: tumor microenvironment