Fig. 5
From: RETRACTED ARTICLE: Palmitoyl transferases act as novel drug targets for pancreatic cancer
Comparison of mutation landscape between PAAD patients with high and low ZDHHC3 expression. A Forest plot showing the most significant mutant genes in ZDHHC3-high and ZDHHC3-low PAAD tumors. B Circular plot showing the mutation status of ZDHHC3-high and ZDHHC3-low PAAD tumors. The genomic density of mutation genes in ZDHHC3-high tumors, in ZDHHC3-low tumors. C, D Proportion of PAAD patients harboring wildtype or mutant KRAS (C) or TP53 (D). E, F GSEA of genes up- (E) or downregulated (F) in association with mutated KRAS, based on ZDHHC3 expression. G Heat map showing the correlation of ZDHHC3 gene expression and the expression of p53-induced genes or p53-suppressed genes in PAAD tumors. The heat map color indicates the correlation coefficient. Red color, positive correlations; green color, negative correlations (ns, not significant, *p < 0.05, and ***p < 0.001)