Fig. 3

Correlation among ZDHHC3 gene expression and immunological status in pan-cancer analysis. A, B Pan-cancer analysis of correlations between ZDHHC3 gene expression and T cell inflamed score (A) and the 18 individual component genes from the established T cell inflamed signature (B). The T cell inflamed score is significantly positively correlated with immunotherapy response in cancer. C Heat map images show the correlation between ZDHHC3 gene expression and 124 immunomodulators such as MHC, immunostimulator, chemokine, and chemokine receptors using the TISIDB database. D–G Correlation between ZDHHC3 gene expression and four immune checkpoints, PD-L1 (D), CTLA-4 (E), PD-1 (F), and LAG-3 (G). The different color dots represent different cancer types. The Y-axis indicates the Pearson correlation coefficient and the X-axis indicates -log₁₀P values. H Heat map images show the correlation between ZDHHC3 gene expression and 28 tumor-infiltrating immune cells in the TME. The heat map color indicates the correlation coefficient. Red color, positive correlations; blue color, negative correlations. The horizontal axis indicates the infiltration levels of immune cells, and the vertical axis indicates the different cancer types