Fig. 1

A Unsupervised analyses of 107 lung adenocarcinomas reveal significant interactions between molecular subtypes and mutation profiles. Tumors are displayed in columns grouped by mRNA expression. Genes are displayed and clustered in rows. Us and other have previously shown that the expression of miR-200s from chromosome 1 (miR-200s-chr1: miR-200a, b, 429) and from chromosome 12 (miR-200s-chr12: miR-200c, 141) were highly correlated within each chromosome group and pooled this information as a mean expression level for chr1 and chr12. B Centroids correlations of gene expression within each group reveals high concordance between the 3 clusters of the cohort, and 3 subtypes from TCGA (TCGA_TRU: Terminal respiratory unit, TCGA_PI: Proximal inflammatory, TCGA_PP: Proximal proliferative). C In univariate model, none of the EMT scores had correlation with outcome. Mean Mir-200/Chr1 expression or individual Mir-200/Chr1 (represented by MiR-429) expression are related to better outcome in DFS and OS both in the cohort, and TCGA data