Fig. 6
From: Pharmacologic inhibition of IL11/STAT3 signaling increases MHC-I expression and T cell infiltration
IL11 highly expressed in CRC indicates unfavorable prognosis. A IL11 mRNA expression in 101 paired CRC and normal samples (n = 101). Tumor vs. normal, log normalized. B IL11 mRNA expression in different T stages (T1 + T2 vs. T3 + T4, n = 23 vs. 78, AJCC ver. 8). *P < 0.05, t test. C IL11 mRNA expression in different N stages (N0 vs. N1 + N2 + N3, n = 63 vs. 38, AJCC ver. 8). **P < 0.01, t test. D IL11 mRNA expression in different M stages (M0 vs. M1, n = 89 vs. 12, AJCC ver. 8). *P < 0.05, t test. (E) IL11 mRNA expression in different AJCC stages (I + II vs. III + IV, n = 58 vs. 43, AJCC ver. 8). ***P < 0.001, t test. F Negative correlation between IL11 and CD8+ T cell infiltration in cancers (TIMER2.0). G IL11 and CD8A mRNA levels were detected by qRT-PCR and their correlation in our cohort (Pearson’s R = -0.388, p < 0.001). H–J Optimal survival cutoff of IL11 expression in local cohort using X-tile. (low vs. high, n = 61 vs. 44, log rank p = 0.003). K–M Optimal survival cutoff of IL11 expression in GSE39582 using X-tile. (low vs. high, n = 131 vs. 182, log rank p = 0.002)