Fig. 5

Identification of Molecular Subtypes in HER2-low Breast Cancer. A Oncoplot of distribution of genomic alterations in different clusters. B Mutation rates of genes stratified by the three clusters. The P value was calculated by Chi-square test or Fisher's exact test based on the number of cases per group featuring the presence or absence of the gene mutation. C Comparison of the percentage of HR+ tumors and HER2 IHC score among the three clusters. The P value was calculated by Chi-square test based on the number of cases per group featuring HR+ or HR− phenotype and the number of cases per group featuring IHC-1 or IHC-2 phenotype. D Kaplan‒Meier survival analysis of OS and DFS identified three subtypes. P value was calculated by Log-rank test. E Univariate Cox regression analysis for OS shown by forest plot (only those with p value < 0.1). The forest plot above the horizontal line showed the univariate Cox regression analysis of altered genes and the below showed the univariate Cox regression analysis of amplified segments