Fig. 4

Bioinformatic screening for differential expression of proteins in serum exosomes. A Principal component analysis (PCA) and B orthogonal partial least squares-discriminant analysis (OPLS-DA) model plot based on the metabolites evaluated in the participant set; C volcano plot displaying differences in protein levels between RIPC participants and controls for the participant set; D heatmaps of the cluster analysis data; volcano plot displaying proteomics differences between RIPC participants and controls; Metascape enrichment network analysis for E top 20 enrichment metabolites and F top 20 enrichment pathways