Fig. 9

Potential significance of immune fluctuation in HCC. A. Grouping method for analyzing variation trend. B. The change trend of subclone number with tumor cell density in HCC. C. The change trend of HCC ploidy with tumor cell density. D. The dispersion tendency of TMB in different groups. E. Relationship between tumor-metapopulation fitness and genomic instability (From reference 27). F. TMB grouping method following the theory of Hanlee P. Ji et al. G. Distribution of TMB in different tumor cell density. H. "Entropy model" describes the competition and balance of different TMB groups in the process of tumor development. The data represent the mean ± S.D. Mann–Whitney U test was used for statistical analysis. *P < 0.05; **P < 0.01; ***P < 0.001