Identification of the MMP family as therapeutic targets and prognostic biomarkers in the microenvironment of head and neck squamous cell carcinoma

Table 4 The cox proportional hazard model of the MMP family faiand six tumor infitrating immune cells in HNSC

	Coef	HR	95%CI_l	95%CI_u	P value	sig
B_cell	− 1.333	0.264	0.015	4.682	0.364
CD8_Tcell	− 0.500	0.607	0.068	5.406	0.654
CD4_Tcell	− 3.189	0.041	0.001	1.499	0.082
Macrophage	3.614	37.115	1.702	809.421	0.022	*
Neutrophil	0.687	1.988	0.047	84.929	0.720
Dendritic	0.753	2.123	0.271	16.613	0.473
MMP1	0.061	1.063	0.909	1.242	0.446
MMP2	− 0.005	0.995	0.803	1.233	0.967
MMP3	0.012	1.012	0.913	1.123	0.815
ILF3	− 0.246	0.782	0.560	1.091	0.148
MMP7	0.015	1.015	0.927	1.112	0.742
MMP8	0.201	1.223	0.854	1.751	0.272
MMP9	0.054	1.055	0.931	1.197	0.401
MMP10	− 0.006	0.994	0.900	1.098	0.908
MMP11	0.004	1.004	0.898	1.122	0.948
MMP12	− 0.087	0.917	0.804	1.046	0.195
MMP13	− 0.023	0.977	0.902	1.058	0.565
MMP14	0.607	1.836	1.363	2.473	0.000	***
MMP15	0.027	1.027	0.845	1.249	0.789
MMP16	− 0.869	0.419	0.264	0.665	0.000	***
MMP17	− 0.186	0.830	0.675	1.022	0.079
MMP19	− 0.455	0.635	0.478	0.842	0.002	**
MMP20	0.252	1.286	0.903	1.833	0.164
MMP21	1.838	6.284	0.084	470.568	0.404
MMP23B	0.054	1.056	0.886	1.258	0.542
MMP24	− 0.076	0.927	0.739	1.162	0.510
MMP25	− 0.275	0.759	0.571	1.010	0.058
MMP26	− 5.121	0.006	0.000	68.064	0.283
MMP27	− 0.034	0.967	0.606	1.541	0.886
MMP28	− 0.045	0.956	0.855	1.068	0.423

ISSN: 1479-5876